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Effect of Steroids on Gd-Enhancing Lesions Before & During Beta Interferon 1a Trtm in Relapsing Remitting MS Neurol 50:403-406, Gasperini,C.,et al, 1998 See this aricle in Pubmed Article Abstract The number and volume of enhancing lesions were analyzed on four serial MR images obtained at monthly intervals(one scan before and three scans after IVMP treatment).A significant reduction in the mean number and volume of enhancing lesions was seen in the first scan after IVMP treatment in all patients.However,while persistently low enhancement was seen in the follow-up scans of patients treated with rIFNB-1a,a rebound effect(i.e., increase in the number and volume of gadolinium-enhancing lesions)was observed in the other patients during the follow-up.These data suggest that rIFNB-1a prolongs the beneficial effect of steroids on the BBB.

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(click to filter results - removes previous filter) gadolinium interferon interferon beta 1-a MRI MRI,abnormal MRI,contrast enhanced MRI,serial multiple sclerosis multiple sclerosis,treatment of steroid steroid therapy,CNS treatment and complications with treatment of neurologic disorder

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